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Syntheses of poly‐deuterated 9( O )‐methano‐Δ 6(9α) ‐prostaglandin I 1 methyl esters
Author(s) -
Tanaka Toshio,
Bannai Kiyoshi,
Hazato Atsuo,
Manabe Kenji,
Kurozumi Seizi
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290608
Subject(s) - chemistry , deuterium , medicinal chemistry , radiochemistry , organic chemistry , nuclear physics , physics
Two types of poly‐deuterated isocarbacyclin [9( O )‐methano‐Δ 6(9α) ‐prostaglandin I 1 ] methyl ester have been synthesized for the use of GC‐MS quantitative analysis as internal standards and for the use of metabolic study as substrates. The 5,13,14‐ 2 H 3 derivative 2 was prepared via H‐D exchange, deuteroboration, and sodium borodeuteride reduction. The 2,2,3,3,4,4‐ 2 H 6 derivatives 3 , 4 were prepared starting from tetrahydrofuran‐d 8 .