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Synthesis of a carbon‐14 labelled peptidyl carbamate human leukocyte elastase inhibitor and its immobilization on a tritiated water soluble polymer
Author(s) -
Banks William R.,
Rypacek Frantisek,
Digenis George A.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290404
Subject(s) - chemistry , carbamate , tritium , isopropyl , elastase , polymer , tritiated water , enzyme , biochemistry , stereochemistry , chromatography , organic chemistry , physics , nuclear physics
A carbon‐14 labelled hemisuccinate peptidyl human leukocyte elastase inhibitor, p‐nitrophenyl‐N‐(1,4‐( 14 C)‐succinyl‐L‐alanyl‐L‐alanyl‐prolylmethyl‐ N‐isopropyl carbamate, and a tritium labelled hydrophilic polymer, poly‐α, β‐[N(2‐hydroxy‐1‐[ 3 H]‐ethyl)]‐D,L aspartamide were prepared and are reported here. The immobilization of the [ 14 C]‐peptidyl carbamate onto the tritiated polymer to afford a double labelled macromolecular inhibitor of human leukocyte elastase is also illustrated.