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Synthesis of 1‐(3,4‐dimethylphenyl)‐1‐[ring‐U‐ 14 C]phenylethane, and of 1‐(3,4‐dimethylphenyl)‐1‐ phenyl[1‐ 14 C]ethane, 14 C‐labeled distillate of ecoscint‐O TM , a biodegradable liquid scintillator
Author(s) -
Saito K.,
Kurihara N.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290310
Subject(s) - acetophenone , chemistry , yield (engineering) , ring (chemistry) , ethanol , medicinal chemistry , distillation , organic chemistry , catalysis , materials science , metallurgy
Abstract 1 ‐(3,4‐Dimethylphenyl)‐ 1 ‐[ring‐U‐ 14 C]phenylethane, and 1‐(3,4‐dimethylphenyl)‐ 1‐phenyl[1 ‐ 14 C]ethane, the 14 C‐labeled organic solvents of Ecoscint‐O TM , a so‐called biodegradable scintillation cocktail, were synthesized by simple two‐step reactions on a milligram scale. [Ring‐U‐ 14 C]acetophenone, and [carbonyl‐ 14 C]acetophenone were reduced with NaBH 4 at the first step, then the resulting 1‐[ring‐U‐ 14 C]phenylethanol, and 1‐ phenyl[1‐ 14 C]ethanol were condensed with o ‐xylene in the presence of H 2 SO 4 at the second step. The radiochemical yield of the overall reaction was 16% on a scale starting with 2 mg of acetophenone, and 70% when 50 mg of acetophenone was added as a carrier.