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Deuterierte herz‐affine technetium‐isonitril‐komplexe
Author(s) -
Wenzel M.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290304
Subject(s) - chemistry , labelling , deuterium , radiochemistry , technetium , nuclear chemistry , biochemistry , nuclear physics , physics
t ‐ Butylisonitril (TBI) and Methoxy‐isobutyl‐isonitril (MIBI) were labelled with deuterium leading to TBI‐d 2 and MIBI‐d 2 or MIBI‐d 5 . After labelling with 99m Tc the organ‐distribution in mice and rats was studied. The deuterated isonitriles showed only a small increase in myocard‐affinity but a significant decrease in blood concentration, so more favourable ratios heart/blood were reached.