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Synthesis of tritium labelled choline analogs
Author(s) -
Rajagopal Srinivasan,
Diksic Mirko
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290213
Subject(s) - chemistry , methyl iodide , enantiomer , iodide , yield (engineering) , tritium , choline , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , materials science , physics , nuclear physics , metallurgy
Abstract The synthesis of choline analogs S(+) and R(‐) 2‐hydroxy, 1‐N, N,‐dimethyl, N‐[ 3 H]‐methyl, propylammonium iodide, 3b , 3a ; R(+) and S(‐) 1‐hydroxy, 2‐N, N‐dimethyl, N‐[ 3 H]‐ methyl, propylammonium iodide, 6b , 6a ; and N, N‐dimethyl, N‐[ 3 H]‐ methyl, propynylammonium iodide, 8 labelled with [ 3 H] at the N‐CH 3 position was achieved with a radiochemical yield of 40% and specific activity of 9.3 Ci/mmol. The preparation of desmethyl compounds, enantiomeric and racemic 1,‐N, N‐dimethylamino 2‐propanol 2a , 2b , 2ab ; enantiomeric and racemic 2,‐N, N‐dimethylamino 1‐propanol 5a , 5b , 5ab is also described.