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Synthesis of a tri‐tritiated heterobifunctional reagent, a potential tool in photoaffinity labeling technology
Author(s) -
Klotz Ph.,
Chatrenet B.,
Coppo M.,
Rousseau B.,
Goeldner M.,
Hirth C.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290205
Subject(s) - chemistry , reagent , methyl iodide , tritiated water , iodide , tritium , photoaffinity labeling , radiochemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor , physics , nuclear physics
The synthesis of the radiolabelled heterobifunctional reagent N‐methyl‐N‐chloroformyl‐N′‐terbutoxycarbonyl‐para‐phenylenediamine A (fig. 1) is presented. In particular, the use of tri‐tritiated methyl iodide in defined reaction conditions allowed the synthesis of this probe B (fig. 1) with a high specific radioactivity (77 Ci/mmol).