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Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([ 3 H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site
Author(s) -
Thurkauf A.,
de Costa B.,
Berger P.,
Paul S.,
Rice K. C.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290202
Subject(s) - chemistry , piperazine , ligand (biochemistry) , reuptake , dopamine , reuptake inhibitor , stereochemistry , pharmacology , receptor , serotonin , biochemistry , organic chemistry , neuroscience , psychology , medicine
A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.