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Synthesis of high specific activity tritiated dihydropyridines: Nicardipine‐ 3 H
Author(s) -
Parnes Howard,
Huan Glenn T.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290112
Subject(s) - chemistry , nicardipine , specific activity , tritiated water , calcium channel blocker , tritium , radiochemistry , calcium , biochemistry , enzyme , organic chemistry , physics , nuclear physics
The synthesis of high specific activity 3‐nitrobenzaldehyde‐[4,6‐ 3 H], a key intermediate in the general synthesis of tritiated 4‐aryldihydropyridines, is described. This substance was then used to prepare the calcium channel entry blocker, nicardipine‐[4′,6′‐ 3 H] at a specific activity of 51 Ci/mmole via the Hantzsch process.