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Synthesis of deuterium labelled lorazepam
Author(s) -
Köves G. J.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290104
Subject(s) - chemistry , lorazepam , benzophenone , deuterium , high performance liquid chromatography , chromatography , organic chemistry , anesthesia , physics , quantum mechanics , medicine
Synthesis of 2 H 3 ‐lorazepam was achieved by modification of literature procedures for the unlabelled drug. The key step in the seven step procedure was the initial one where upon selective exchange of 2‐amino‐5,2′‐dichloro‐benzophenone was obtained in deuterated acids. Purifications were carried out by preparative HPLC. The 2 H 3 ‐lorazepam is suitable for use as an internal standard in GC‐MS‐NICI‐SIM quantitative analysis in forensic case work.