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Synthesis of [ 119m Sn]‐mesoporphyrin IX dichloride
Author(s) -
Denissen Jon F.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281210
Subject(s) - chemistry , metalation , porphyrin , heme , yield (engineering) , porphyria , tin , stereochemistry , biochemistry , enzyme , organic chemistry , medicine , materials science , metallurgy
Tin mesoporphyrin IX dichloride (Sn‐MPCl 2 ) is a heme oxygenase inhibitor of current clinical interest for the treatment of neonatal hyperbilirubinemia. The synthesis of [ 119m Sn]‐MPCl 2 for drug metabolism and disposition studies is reported. [ 119m Sn]‐MPCl 2 was prepared in 60% radiochemical yield by metalation of the porphyrin nucleus of mesoporphyrin IX dihydrochloride with tin(II)‐119m acetate. The product had a specific activity of 43.4 mCi/mmol and a radiochemical purity of 99%, as determined by radio‐HPLC analysis.