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Carbon‐14 labelling of FCE 24578, an immunomodulating agent
Author(s) -
Angiuli Patrizia,
Vicario Gian Piero
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281014
Subject(s) - chemistry , labelling , yield (engineering) , carbon 14 , acetonitrile , benzoic acid , radiochemistry , specific activity , carbon fibers , nuclear chemistry , organic chemistry , biochemistry , materials science , physics , quantum mechanics , composite number , metallurgy , composite material , enzyme
Two syntheses of radiocarbon labelled FCE 24578, namely 2‐cyano‐3‐(1,4‐dihydro‐1‐phenyl‐[1]‐benzothiopyrano[4,3‐c]pyrazol‐3‐yl)‐3‐oxo‐N‐phenylpropanamide, are reported. The former gave, employing [1‐ 14 C]acetonitrile as labelled starting material and with an overall radiochemical yield of 39%, [cyano‐ 14 C]FCE 24578, 97% radiochemically pure and with a specific radioactivity of 299 MBq/mmol. The latter was carried out with [ring‐U‐ 14 C]benzoic acid to give [phenyl‐U‐ 14 C]FCE 24578, 96% radiochemically pure, with specific radioactivity of 400 MBq/mmol in an overall radiochemical yield of 40%.