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Synthesis of deuterium labelled analogs of the ubiquinone headgroup
Author(s) -
Dieks Henrik,
Beyer Klaus
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280915
Subject(s) - chemistry , deuterium , benzoquinone , labelling , stereochemistry , 1,4 benzoquinone , quinone , organic chemistry , biochemistry , quantum mechanics , physics
Deuterium labelled analogs of 2,3 ‐ dimethoxy ‐ 5 ‐ methyl ‐ 1,4 ‐ benzoquinone (2,3 ‐ dimethoxy ‐ 5 methyl[ 2 H 3 ] ‐ 1,4 ‐ benzoquinone; 2,3 ‐ dimethyoxy[ 2 H 6 ] ‐ 5 ‐ methyl ‐ 1,4 ‐ benzoquinone; 2,3 ‐ dimethoxy[ 2 H 6 ] ‐ 5 ‐ methyl[ 2 H 3 ] ‐ 1,4 ‐ benzoquinone) were prepared in five steps starting from 3,4,5 ‐ trihydroxybenzoic acid. The proposed synthetic route results in 100% specific labelling and gives good overall yields. Mass spectra of the labelled derivatives will be briefly discussed.