Premium
[ 82 Br]cisplatin derivative: A potential biological model for cisplatin
Author(s) -
Tinker N. D.,
Sharma H. L.,
McAuliffe C. A.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280811
Subject(s) - chemistry , cisplatin , derivative (finance) , medicinal chemistry , stereochemistry , platinum , nuclear chemistry , combinatorial chemistry , organic chemistry , chemotherapy , surgery , medicine , financial economics , economics , catalysis
The complex cis‐[Pt(NH 3 ) 2 82 Br 2 ] has been prepared as a possible model for cisplatin, cis‐[Pt(NH 3 ) 2 Cl 2 ]. The stability of cis‐[Pt(NH 3 ) 2 82 Br 2 ] was investigated in 0.9% saline solution and sterile water. In both cases the 82 Br label was rapidly displaced in the first hour (t 1/2 = 73 min and 96 min respectively). Thus, cis‐[Pt(NH 3 ) 2 82 Br 2 ]cannot be used for determining the fate of the labile ligands of cisplatin.