Premium
Synthesis of n‐butyl [3‐ 13 C]acrylate
Author(s) -
Šmejkal J.,
Hanuš V.,
Linhart I.,
Elbert T.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280704
Subject(s) - chemistry , halogenation , yield (engineering) , methyl acrylate , cleavage (geology) , acrylate , iodide , methyl iodide , organic chemistry , medicinal chemistry , copolymer , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy , polymer
A four step synthesis of n‐butyl [3‐ 13 C]acrylate from [ 13 C]methyl iodide is described. The procedure involves methylation of butyl acetoacetate, subsequent bromination, alkaline cleavage and, finally, dehydrobromination using cyclohexyldimethylamine. The overall yield was 5%.