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Synthese du methyl [(chloro‐2 ethyl)‐3 nitroso‐3 ureido]‐3 didesoxy‐2, 3 α‐ D ‐ arabino ‐hexopyrannoside marque AU carbone‐14 OU − AU carbone‐13 (CY 233 ‐ SR 90098)
Author(s) -
Sion R.,
Schumer A.,
Van Durme E.,
Gouyette A.,
Geslin M.,
Fournier J. P.,
Berger Y.,
Roger P.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280605
Subject(s) - chemistry , anomer , substituent , stereochemistry , urea , ring (chemistry) , medicinal chemistry , organic chemistry
CY 233 (Ecomustine or SR 90098) is a new antitumour nitrosourea: it is characterized by a 2‐chloroethylnitrosourea substituent on a dideoxycarbohydrate. It has been labelled with 14 C on a) the carbonyl group of the urea in four stages starting with 14 COCl 2 , b) the second carbon of the chloroethyl group in four stages starting with [ 14 C] ethanolamine, and c) on the methyl group on the anomeric centre of the carbohydrate in three stages starting with 14 CH 3 OH. The final position was also labelled with 13 C starting with 13 CH 3 OH. These differently labelled compounds are suitable for mechanistic studies of antitumour activity.