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Syntheses of homologous, tritium‐labelled photoaffinity analogs of the natural juvenile hormones JH I, JH II, and JH III
Author(s) -
Ujváry István,
Eng WaiSi,
Prestwich Glenn D.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280108
Subject(s) - chemistry , acylation , tritium , juvenile hormone , photoaffinity labeling , diazirine , stereochemistry , hormone , biochemistry , receptor , catalysis , physics , nuclear physics
Enantiomerically enriched (≥92% e.e.) tritium‐labelled diazoacetate photoaffinity analogs EBDA and EHDA (each 58 Ci/mmol) and EFDA (14 Ci/mmol) were prepared from the corresponding tritiated juvenile hormone (JH) homologs JH I, JH II, and JH III in two steps. Selective reduction of the ester group and subsequent acylation gave the target compounds.