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Synthesis of Some 3 H labeled 2′, 3′‐dideoxynucleosides of pharmacological interest
Author(s) -
Taylor George F.,
Kepler John A.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270611
Subject(s) - chemistry , tritium , hypoxanthine , adenosine deaminase , adenosine , ribonucleoside , catalysis , tritium illumination , nucleoside , pyrimidine , radiochemistry , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , enzyme , rna , physics , nuclear physics , gene
[Pyrimidine‐5‐ 3 H]2′, 3′‐dideoxycytidine and [ribose 2,3‐ 3 H]2′, 3′‐dideoxyinosine are prepared by catalytic reduction with tritium gas. [Adenine‐8‐ 3 H]2′3′‐dideoxyadenosine is prepared by catalytic exchange with tritium gas. [Hypoxanthine‐8‐ 3 H]2′,3′‐dideoxyinosine is prepared by the action of adenosine deaminase on [adenine‐8‐ 3 H]2′,3′‐dideoxy‐adenosine.