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Synthesis of [ 14 C] labelled N‐nitro methylamine and N‐nitro dimethylamine
Author(s) -
Braun H.,
Plesch W.,
Frei E.,
Hassel M.,
Wiessler M.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270604
Subject(s) - chemistry , methylamine , dimethylamine , nitration , diazomethane , nitro , nitro compound , methylamines , methylation , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , gene
N‐nitro [ 14 C]methylamine was synthesized by the alkaline cleavage of N‐nitro[methyl‐ 14 C] methylurethane obtained by nitration of [N ‐ methyl‐ 14 C] methylurethane. N‐nitro[N‐methyl‐ 14 C]dimethylamine could be obtained by methylation of monomethylnitramine with [ 14 C] diazomethane.