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The synthesis of tritium labeled dimethylethanolamine and monomethylethanolamine
Author(s) -
Kanfer Julian N.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270202
Subject(s) - chemistry , ethanolamine , tritium , formaldehyde , thin layer chromatography , schiff base , thin layer , radiochemistry , chromatography , nuclear chemistry , organic chemistry , layer (electronics) , stereochemistry , physics , nuclear physics
A simple and efficient procedure has been developed for the synthesis of [ 3 H]monomethylethanolamine and [ 3 H]dimethyl‐ethanolamine. Schiff base formation between formaldehyde and either ethanolamine or monomethylethanolamine was followed by Na B[ 3 H] 4 reduction. The reaction products were obtained from preparative thin layer chromatography plates.