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13 C‐labelling of N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)
Author(s) -
Williams C. H.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270112
Subject(s) - chemistry , mptp , monoamine oxidase , labelling , neurotoxin , monoamine oxidase b , pyridine , enzyme , stereochemistry , spectral analysis , medicinal chemistry , dopamine , biochemistry , physics , dopaminergic , quantum mechanics , spectroscopy , neuroscience , biology
N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydro pyridine (MPTP) is converted to a potent neurotoxin by the enzyme monoamine oxidase. Two different 13 C‐derivatives of the compound have been prepared for detailed n.m.r. studies of the enzyme reaction. Mass spectral analysis of the labelled compounds showed that incorporation of 13 C exceeded 90% in each case.