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Synthesis of tritium‐labelled stobadine, a new cardioprotective agent
Author(s) -
Marko Vladimir,
Filip Jiří,
Uhrín Dušan,
Trnovec Tomáš,
Beneš Luděk
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270106
Subject(s) - chemistry , indole test , halogenation , tritium , phosphate buffered saline , catalysis , radiochemistry , specific activity , nuclear chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , chromatography , enzyme , physics , nuclear physics
Synthesis of dihydrochloride of (−)‐cis‐2,8‐dimethyl‐6‐[ 3 H]‐2,3,4,4a,5,9b‐hexahydro‐1H‐pyrido[4,3b]indole by catalytic reductive dehalogenation of dihydrochloride of (−)‐cis‐2,8‐dimethyl‐6‐bromo‐2,3,4,4a,5,9b‐hexahydro‐1H‐pyrido[4,3b]indole is described together with the reaction conditions of the tritiation using 5% Pd/BaSO 4 (UVVVR) in 0.1 M phosphate buffer pH 7.4. Specific activity of the product was 0.9 TBq.mmol −1 , its radiochemical purity 96%.