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Radioactively labelled epoxides. Part VI. tritium‐labelled mono‐ and dimethyl substituted phenyl oxiranes (styrene oxides)
Author(s) -
Setiabudi Frans,
Oesch Franz,
Platt Karl L.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580251107
Subject(s) - chemistry , tritium , epoxide , styrene , epoxide hydrolase , organic chemistry , enzyme , catalysis , copolymer , physics , microsome , polymer , nuclear physics
Abstract Tritium‐labelled ( E )‐ and ( Z )‐2,3‐dimethyl‐2‐phenyl oxirane 4 , ( E )‐ and ( Z )‐2‐methyl‐3‐phenyl oxirane 7 and 2,2‐dimethyl‐3‐phenyl oxirane 11 have been prepared by reduction of the corresponding bromoketones with sodium borotritide to the corresponding bromohydrins followed by cyclization to the oxiranes. These oxiranes were successfully used as diagnostic substrates to distinguish between different forms of epoxide hydrolase and glutathione transferase.