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Investigation of the catalytic deuteration of N‐acetyl‐DL‐3,4‐dehydroproline amide
Author(s) -
Oehlke J.,
Niedrich H.,
Zöpfl H.J.,
Franke P.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580251006
Subject(s) - chemistry , deuterium , tritium , amide , catalysis , hydrogen , catalytic hydrogenation , labelling , organic chemistry , biochemistry , physics , nuclear physics , quantum mechanics
Abstract As a model for the tritium labelling of peptides the catalytic deuteration of N‐acetyl‐DL‐3,4‐dehydroproline amide was investigated by means of mass spectrometric measurements. The unwanted incorporation of hydrogen instead of deuterium, found especially in the presence of water, was compensated partially by an incorporation of deuterium proceeding additionally to the saturation of the double bond. Both effects were most intensive in the presence of water and rose with ascending catalyst amounts and descending pH.