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Synthesis of tritium‐labelled fenoxycarb and S‐31183, two phenoxyphenyl ether insect growth regulators
Author(s) -
Boehm Marcus F.,
Prestwich Glenn D.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250913
Subject(s) - chemistry , tritium , ether , insect growth regulator , insect , radiochemistry , stereochemistry , organic chemistry , ecology , physics , nuclear physics , biology
Abstract Using 4‐( m ‐bromophenoxy)phenol as an intermediate, two brominated phenoxyphenyl ether IGRs were prepared. Reductive tritiodebromination of the bromo IGRs furnished high specific activity tritium‐labelled fenoxycarb and S‐31183, which can be used to study the molecular action of these two potent juvenoid‐type IGRs.