Premium
The synthesis of [ 14 C] and [ 3 H 2 ] SK&F l‐94901. A novel thyromimetic
Author(s) -
Crowe A M,
Lawrie K W M,
Saunders D
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250710
Subject(s) - chemistry , yield (engineering) , stereochemistry , radiochemistry , metallurgy , materials science
A novel thyromimetic SK&F L‐94901, L‐3,5‐dibromo‐3′‐(6‐oxo‐1, 6‐dihydro pyridazin‐3‐ylmethyl) thyronine, has been labelled with 14 C and 3 H for drug metabolism and nuclear binding studies. A six stage synthesis from [β‐ 14 C] tyrosine is described. The overall radiochemical yield was 13.7%. Syntheses of [ 3 H 2 ] SK&F L‐94901 of 1.22Ci mmol −1 and 13.9Ci mmol −1 are described, and the instability of these compounds noted.