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Labeling of a serotoninergic ligand with 18 F : [ 18 F] setoperone
Author(s) -
Crouzel C.,
Venet M.,
Irie T.,
Sanz G.,
Boullais C.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250407
Subject(s) - chemistry , derivative (finance) , radiochemistry , nitro , nucleophilic substitution , ligand (biochemistry) , nucleophile , aqueous solution , positron emission tomography , medicinal chemistry , receptor , nuclear medicine , organic chemistry , biochemistry , medicine , alkyl , financial economics , economics , catalysis
Setoperone has been labeled with 18 F to visualize the serotoninergic receptors by positron emission tomography. The synthesis is carried out by a nucleophilic substitution from a nitro derivative of setoperone with 18 F − . The synthesis of nitro‐derivative is described as well as the different trials of recovery of ion 18 F − from neon or aqueous target. The considered technique of labeling allow to obtain from 7.4 GBq (200 mCi) 18 F, 1.5 to 2 GBq (40–50 mCi) of [ 18 F]setoperone, 110 minutes after the end of bombardment. The specific activity obtained from this quantity of radioactivity is about 37 GBq/μMol (1 Ci/μMol).