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Synthesis of D/D‐norepinephrine‐ (phenyl‐U‐ 13 C)
Author(s) -
Weisz Adrian,
Markey Sanford P.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250113
Subject(s) - chemistry , catechol , yield (engineering) , ketone , hydrolysis , friedel–crafts reaction , adduct , acylation , norepinephrine , catalysis , medicinal chemistry , chemical synthesis , organic chemistry , stereochemistry , dopamine , in vitro , biochemistry , materials science , neuroscience , metallurgy , biology
The synthesis of phenyl‐U‐carbon‐13 labelled D,L‐norepinephrine from catechol‐U‐ 13 C in three steps is described. In the first step, the Friedel‐Crafts acylation of the labelled part with N‐phthaloylglycylchloride yielded the aromatic ketone adduct. Subsequent hydrolysis and catalytic hydrogenation produced the desired product in a 5% overall yield.