Premium
Synthesis of c‐9‐ 14 C‐1,8‐dihydroxy‐3‐carboxyanthraquinone
Author(s) -
De Witte P.,
Lemli J.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250104
Subject(s) - chemistry , yield (engineering) , stereochemistry , total synthesis , condensation , medicinal chemistry , materials science , physics , metallurgy , thermodynamics
The synthesis of C‐9‐ 14 C‐rhein is reported, 14 CO 2 is used as a 14 C‐source. After preparing 14 C‐1,8‐dimethoxy‐3‐methylanthraquinone by a condensation reaction, the product is demethylated and the 3‐methyl group converted to the corresponding 3‐carboxy group. The radio‐active yield of the total synthesis, starting with 1 Ci 14 CO 2 is 6,9% (6,9 mCi); 352 mg 14 rhein is produced with a specific activity of 55,7 mCi/mmol.