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Synthesis of [6β,7β‐ 2 H]‐ and [6β,7β‐ 3 H]‐21‐hydroxy‐19‐norpregn‐4‐ene‐3,20 dione
Author(s) -
Arunachalam Thangavel,
Gut Marcel
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240608
Subject(s) - chemistry , diene , catalysis , ene reaction , medicinal chemistry , catalytic hydrogenation , stereochemistry , organic chemistry , natural rubber
The (6β,7β‐ 2 H) and (6β,7β‐ 3 H) labelled 19‐nordeoxycorticosterone 6 was prepared by selective catalytic hydrogenation of 21‐hydroxy‐19‐norpregna‐4,6‐diene‐3,20‐dione ( 5 ) which in turn was synthesized from 19,21‐dihydroxypregna‐4,6‐diene‐3,20‐dione ( 1 ).