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Possible drugs labelled with 14 C.IV. 1 synthesis of D‐pheylalaninyl‐prolyl‐arginine aldehyde labelled in the guanidino group
Author(s) -
Koltai E.,
Bajusz S.,
Széll E.,
Zólyomi G.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240607
Subject(s) - chemistry , arginine , aldehyde , ornithine , stereochemistry , lactam , amino acid , organic chemistry , biochemistry , catalysis
Abstract α‐tert‐Butyloxycarbonyl‐ω‐benzyloxycarbonyl‐[guanido‐ 14 C]arginine was prepared by reacting α‐tert‐butyloxycarbonyl‐ornithine with N‐benzyloxy‐carbonyl‐S‐methyl‐[ 14 C]isothiourea, and it was transformed to D‐phenylalaninyl‐prolyl‐[guanido‐ 14 C]arginine aldehyde, via ω‐benzyloxycarbonyl‐[guanido‐ 14 C]‐arginine lactam.