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Possible drugs labelled with 14 C. III. Synthesis of D‐[3‐ 14 C]phenylalaninyl‐L‐propyl‐L‐arginine aldehyde and L‐tyrosinyl‐D‐methionyl‐glycyl‐L‐[3‐ 14 C]phenylalaninyl‐L‐proline amide
Author(s) -
Koltai E.,
Bajusz S.,
Széll E.,
Zólyomi G.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240606
Subject(s) - chemistry , proline , aldehyde , diastereomer , arginine , amide , stereochemistry , amino acid , organic chemistry , catalysis , biochemistry
D‐[3‐ 14 C] Phenylalaninyl‐L‐prolyl‐L‐arginine aldehyde (GYKI‐14166) and L‐tyrosyl‐D‐methionyl‐glycyl‐L‐ [3‐ 14 C] phenylalaninyl‐L‐proline amide (GYKI‐14238) were prepared starting from D‐ [3‐ 14 C] phenylalaninyl‐L‐proline and L‐ [3‐ 14 C] phenylalaninyl‐L‐proline, respectively. The diastereomeric pairs obtained by coupling 2,4,5‐trichlorophenyl benzyloxycarbonyl‐D,L‐[3‐ 14 C] phenylalaninate to L‐proline and by subsequent deprotection were separated on silica gel.