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Synthesis and 1 H‐nmr of deuterium labeled D,L‐homoserine lactone hydrochlorides
Author(s) -
Ramalingam Kondareddiar,
Woodard Ronald W.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240404
Subject(s) - chemistry , lactone , deuterium , homoserine , stereochemistry , proton nmr , deuterium nmr , chemical shift , carbon 13 nmr , biochemistry , quorum sensing , physics , quantum mechanics , virulence , gene
The synthesis of six regiospecific deuterated D,L‐homoserine lactone hydrochlorides from the appropriately deuterated 2‐bromo‐1‐(tetrahydropyranyloxy) ethanes which were obtained by reduction of the corresponding ethyl bromoacetates are described. The proton nmr of each lactone is recorded and the chemical shift and coupling constants are reported.