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Synthesis of 2 H 8 ‐leukotriene B 4
Author(s) -
Dawson Michael,
Vine John H.,
Forrest Michael J.,
McGee Colette M.,
Brooks Peter M.,
Watson Thomas R.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240308
Subject(s) - chemistry , deuterium , leukotriene c4 , arachidonic acid , leukotriene , nuclear chemistry , organic chemistry , enzyme , immunology , nuclear physics , physics , asthma , biology
A semi‐synthetic method for the preparation of deuterated leukotriene B 4 ( 2 H 8 ‐LTB 4 ) from eicosatetraynoic acid (ETYA) is described which involves reduction of ETYA to deuterated arachidonic acid ( 2 H 8 ‐AA) with deuterium gas and then biological conversion of this material to 2 H 8 ‐LTB 4 by rat peritoneal polymorphonuclear leukocytes (PMNs).