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Microscale synthesis of high specific activity 3 H‐nitroglycerin
Author(s) -
Kawamoto J. J.,
Brien J. J.,
Marks G. G.,
Nakatsu K.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240206
Subject(s) - chemistry , microscale chemistry , yield (engineering) , chromatography , nitroglycerin (drug) , molar ratio , specific activity , organic chemistry , catalysis , enzyme , medicine , materials science , mathematics education , mathematics , anesthesia , metallurgy
The synthesis and purification of 3 H‐nitroglycerin (glyceryl trinitrate, GTN) from commercially available 3 H‐glycerol of high specific activity are described. The optimum microscale reaction conditions were defined. Purification of the product by thin‐layer chromatography produced 3 H‐GTN with an overall molar yield of 65% and a radiochemical purity of 99.0%.