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Synthesis of 1‐(2,3‐dihydroxypropyl)‐2‐nitro‐1H‐imidazole‐2‐ 14 C and N‐(2‐hydroxyethyl)‐2‐(2‐nitro‐1H‐imidazol‐1‐YL‐2‐ 14 C) acetamide
Author(s) -
Fong Mary T.,
Leaffer Morris A.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230910
Subject(s) - chemistry , nitro , acetamide , imidazole , acute toxicity , medicinal chemistry , stereochemistry , nitro compound , metabolite , toxicity , organic chemistry , biochemistry , alkyl
We have prepared the 14 C‐labeled analogs of NSC 261036, 1‐(2,3‐dihydroxypropyl)‐2‐nitro‐1H‐imidazole‐2‐ 14 C, and NSC 301467, N‐(2‐hydroxyethyl)‐2‐(2‐nitro‐1H‐imidazol‐1‐y1‐2‐ 14 C) acetamide, for pharmacological, drug distribution, and mechanisms of action studies. The latter is an analog designed for lower toxicity and improved properties. The former is a metabolite of, and appears to be less toxic than, misonidazole.