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Synthesis of a radiobrominated analog of SCH 23390, a selfctive dopamine D 1 /DA 1 antagonist
Author(s) -
De Jesus Onofre T.,
Van Hoffaert Glenn J.,
Glock Dana,
Goldber Leon I.,
Friedman Arnold H.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230902
Subject(s) - sch 23390 , chemistry , antagonist , dopamine , dopamine antagonist , d 1 , dopamine receptor , ligand (biochemistry) , receptor , biochemistry , neuroscience , psychology
A radiobrominated analog of SCH 23390, a selective dopamine D 1 /DA 1 antagonist was prepared. Radiochemical yields of up to 60% were obtained within 15 minutes reaction at room temperature. The synthesis was validated by performing both physical (NMR and mass spectroscopy) and biological tests on the product. Preliminary studies suggest that 75 Br‐labelled SCH 23390 analog would be a useful ligand for the studies of CNS dopamine D 1 receptors by positron emission tomography.