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Specifically labelled beta‐carbolines for biomedical investigations
Author(s) -
Gynther J.,
Huhtikangas A.,
Auriola S.,
Juvonen H.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230707
Subject(s) - chemistry , tryptamine , deuterium , glyoxylic acid , radiochemistry , tritium , hydrochloride , labelling , formaldehyde , nuclear chemistry , specific activity , organic chemistry , biochemistry , physics , quantum mechanics , nuclear physics , enzyme
Five radioactive and three deuterium labelled 1.2,3,4‐tetrahydro‐beta‐carbolines (THBCs) have been synthesized from tryptamine hydrochloride or 5‐methoxytryptamine hydrochloride and formaldehyde, glyoxylic acid or pyruvic acid. Radioactive labelling was performed using [ 14 C] and [ 3 H]labelled compounds. while the deuterium labels were introduced using lithium aluminium deuteride. The specific activities obtained for [ 14 C] labelled THBCs varied between 1.0 and 5.0 mCi/mmol, while a value of 30.1 mCi/mmol was obtained for the tritiated compound. The isotopic purities of the deuterated THBCs were in the range of 76.3 ‐ 96.2 %.