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Preparation of no‐carrier‐added 4‐[ 131 i]iodoantipyrine using chloramine‐T
Author(s) -
Boothe Thomas E.,
Finn Ronald D.,
Vora Manhar M.,
Kothari J Paresh,
Emran Ali M.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230504
Subject(s) - chemistry , chloramine t , yield (engineering) , reagent , chromatography , aqueous solution , radiochemistry , chloramine , nuclear chemistry , organic chemistry , materials science , chlorine , metallurgy
The blood flow reagent 4‐iodoantipyrine, labelled with 131 I or 125 I, was prepared by allowing aqueous antipyrine to react with either no‐carrier‐added 131 I − I or 125 I − I in the presence of chloramine‐T. Purification of 4‐[ 131 I]iodoantipyrine was performed by reversed‐phase liquid chromatography and resulted in a 99 ± 1% radiochemically pure product in an overall 90% yield. The use of iodogen for oxidation of the radioiodine was also investigated.