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Synthesis of [ 14 C]zolpidem
Author(s) -
Allen John,
Tizot André
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230407
Subject(s) - zolpidem , chemistry , pharmacokinetics , potassium cyanide , hypnotic , yield (engineering) , benzodiazepine , chemical synthesis , cyanide , pharmacology , stereochemistry , organic chemistry , biochemistry , receptor , in vitro , medicine , materials science , metallurgy , insomnia
The synthesis of [ 14 C]Zolpidem, a new hypnotic agent having a non‐benzodiazepine structure, is described. This compound was synthesised in a 64% overall radio‐chemical yield from potassium[ 14 C]cyanide and with a specific radioactivity of 56 mCi/mmol. It was used for pharmacokinetic and drug metabolism studies.