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Synthesis of carbon‐14‐labeled sodium palmoxirate and its coenzyme a ester
Author(s) -
Weaner Larry E.,
Hoerr David C.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230403
Subject(s) - chemistry , oxalyl chloride , tetrahydrofuran , sodium , cofactor , coenzyme a , carbon 14 , chloride , organic chemistry , carbon fibers , enzyme , physics , materials science , quantum mechanics , solvent , composite number , reductase , composite material
Synthetic procedures for the preparation of carbon‐14‐labeled sodium palmoxirate (TDGA), labeled either in the carboxyl position or in the tetradecyl hydrocarbon chain, are described. In addition, the synthesis of the coenzyme A ester of TDGA‐ 14 C with a specific activity of 51 mCi/mmol is reported. The coenzyme A ester was prepared by formation of the acyl chloride with oxalyl chloride followed by reaction with coenzyme A (CoA) in a borate‐buffered tetrahydrofuran solution. Purification methods and analytical and stability data are reported for the compounds.