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Synthesis of deuterated eicosanoids
Author(s) -
Meese Claus O.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230307
Subject(s) - chemistry , arachidonic acid , deuterium , lipoxygenase , cyclooxygenase , prostaglandin endoperoxide synthase , eicosanoid , biochemistry , enzyme , physics , quantum mechanics
Deuterated lipoxygenase and cyclooxygenase derivatives of eicosatetraenoic acid (arachidonic acid) and their metabolites are indispensable tools for organic trace analysis, biomedical studies, and mechanistic investigations on the corresponding endogenous (unlabelled) eicosanoids. Methods for the preparation of deuterated eicosanoids are reviewed.