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Tritiated peptides. Part 16 1 . Synthesis of [ 3 H‐Tyr 8 ]‐physalaemin
Author(s) -
Brundish D. E.,
Wade R.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230103
Subject(s) - chemistry , halogenation , tritium , radiochemistry , specific activity , stereochemistry , organic chemistry , enzyme , nuclear physics , physics
Abstract The title compound was synthesized with a specific activity of 30 Ci mmol −1 and with radiochemical purity of 96% by iodination of the sulphoxide followed by catalytic tritiation of an isolated fraction. Iodination and reduction studies on model peptides are reported. Alternative philosophies for preparing tritiated peptides are critically discussed.