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Synthesis of N‐(2, 5‐[2‐ 13 C]dimethyl‐1H‐pyrrol‐1‐YL)‐6‐(4‐morpholinyl)‐3‐Pyridazinamine hydrochloride
Author(s) -
Mola Nunzio Di,
Bellasio Elvio,
Ferrari Pietro,
Zerilli Luigi F.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221210
Subject(s) - chemistry , hydrochloride , medicinal chemistry , stereochemistry , organic chemistry
N‐(2, 5‐[2‐ 13 C]dimethyl‐1H‐pyrrol‐1‐yl)‐6‐(4‐morpholinyl)‐3‐pyridazinamine hydrochloride ([2‐ 13 C]methyl MDL‐899), a new antihypertensive agent, was synthesized for metabolic studies, in five steps via 2, 5‐[1‐ 13 C]hexanedione, and characterized by 1 H‐ and 13 C‐NMR, IR, and MS.