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Synthesis of 14 C‐labeled indeloxazine hydrochloride (YM‐08054), a cerebral activator
Author(s) -
Arima Hideki,
Tamazawa Kazuharu
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221203
Subject(s) - chemistry , hydrochloride , yield (engineering) , morpholine , potassium , nuclear chemistry , potassium cyanide , specific activity , radiochemistry , activator (genetics) , cyanide , medicinal chemistry , organic chemistry , biochemistry , enzyme , materials science , metallurgy , gene
Indeloxazine hydrochloride, (±)‐2‐[(inden‐7‐yloxy)methyl]morpholine hydrochloride (YM‐08054), a new cerebral activator, was labeled with 14 C for metabolic studies. The labeled material with a specific activity of 14.9 mCi/mmol was synthesized in a 42.8% radiochemical yield from potassium [ 14 C]cyanide via a process of ten steps.