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Synthesis of DL‐[2‐ 13 C, 15 N]aspartic acid
Author(s) -
Baxter Robert L.,
Abbot Elaine M.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221202
Subject(s) - chemistry , strecker amino acid synthesis , paraformaldehyde , aspartic acid , ammonium chloride , ammonium acetate , ammonium , chloride , organic chemistry , stereochemistry , amino acid , biochemistry , catalysis , high performance liquid chromatography , enantioselective synthesis
Abstract A synthesis of the title compound from [ 13 C]paraformaldehyde and [ 15 N]ammonium chloride via ethyl 2‐(1, 3‐[2‐ 13 C]dithianyl) acetate 3a is described. Ethyl[3‐ 13 C]3‐oxopropanoate derived in situ from 3a was converted by a stepwise strecker procedure to DL‐[2‐ 13 C, 15 N]aspartic acid 7a .