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Synthesis of tritium labelled DSP 4, a selective noradrenaline neurotoxin
Author(s) -
Sahlberg Christer,
Gawell Lars
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221106
Subject(s) - chemistry , neurotoxin , tritium , sodium , radiochemistry , hydride , alcohol , specific activity , medicinal chemistry , nuclear chemistry , organic chemistry , enzyme , biochemistry , metal , physics , nuclear physics
DSP 4 (N‐(2‐Chloroethyl)‐N‐ethyl‐2‐bromobenzylamine, 1) is a neurotoxin, selective for neuronal noradrenaline (NA). Tritium labelled DSP 4 (4) with a specific activity of 105 mCi/mmol was prepared. The key step in the synthesis is a reduction of the aminoester 2 with activatated sodium boro [ 3 H]hydride thus forming the alcohol 3.