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Preparation of tritium labelled benzamide dopamine‐D 2 lignads at high specific activity
Author(s) -
Gawell Lars,
Hall Häkan,
Köhler Christer
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221006
Subject(s) - chemistry , benzamide , tritium , pyrrolidine , moiety , dopamine , specific activity , tritium illumination , chloride , radiochemistry , stereochemistry , organic chemistry , enzyme , physics , neuroscience , nuclear physics , biology
A method for the preparation of tritium labelled potential neuroleptics of the benzamide class possessing highly potent dopamine‐ D 2 binding properties, is described. The pyrrolidine moiety of the molecule is labelled with tritium by hydrogenation, to a specific activity of up to 58 Ci/mmol and subsequently reacted with an acid chloride. The specificity of the label is confirmed by 3 H‐NMR.