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Synthesis of 14‐methyl[2,3‐ 3 H]hexadecanoic acid
Author(s) -
Helmich O.,
Streibl M.,
Filip J.,
Hradec J.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220907
Subject(s) - chemistry , yield (engineering) , catalysis , organic chemistry , fatty acid , nuclear chemistry , medicinal chemistry , metallurgy , materials science
14‐Methyl[2,3‐ 3 H]hexadecanoic acid of a specific radioactivity of 51 Ci/mmol was prepared starting from 12‐methyl‐tetradecanoic acid isolated from wool fat. This fatty acid was converted into 12‐methyltetradecanal which was reacted with ethyl diethylphosphonoacetate to yield 14‐methylhexadecen‐2‐oic acid. The resulting compound was tritiated with gaseous 3 H 2 in the presence of a 5% Pd/BaSO 4 catalyst. The reaction in dried dioxane gave products of a specific radioactivity corresponding to 87.9% of the theoretical value.