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Stereospecific synthesis of L‐[1,4‐ 13 C 2 ]aspartic acid, L‐β‐([ 13 C]cyano)alanine and L‐[4‐ 13 C]aspartic acid
Author(s) -
Röhm Klaus H.,
van Etten Robert L.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220906
Subject(s) - stereospecificity , aspartic acid , chemistry , alanine , fumaric acid , stereochemistry , amino acid , organic chemistry , catalysis , biochemistry
A convenient stereospecific synthesis of L‐aspartic acid, 13 C‐labelled in both carboxyls, is described. The crucial step of the procedure is the conversion of [1,4‐ 13 C 2 ]fumaric acid to L‐aspartic acid utilizing the enzyme L‐aspartase. In addition, an improved synthesis of L‐β([ 13 C]cyano)alanine was developed. This compound is easily converted to L‐[4‐ 13 C]aspartic acid.