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Synthesis of nedocromil sodium labelled with tritium, deuterium and carbon‐14
Author(s) -
Wilkinson D J,
Lockley W J S
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220903
Subject(s) - chemistry , tritium , deuterium , sodium , carbon 14 , carboxylate , nuclear chemistry , radiochemistry , nedocromil sodium , carbon fibers , medicinal chemistry , organic chemistry , inorganic chemistry , medicine , physics , alternative medicine , materials science , pathology , quantum mechanics , composite number , nuclear physics , composite material , placebo
Nedocromil sodium labelled with carbon‐14 has been prepared by a Claisen reaction between diethyl [1,2‐ 14 C]‐ethanedioate and methyl 6‐ethanoyl‐1‐ethyl‐1,4‐dihydro‐7‐hydroxy‐4‐oxo‐8‐propylquinoline‐2‐carboxylate. The 2 H‐ and 3 H‐labelled materials are readily prepared by rhodium(III) chloride catalysed exchange with the appropriate isotopically labelled water.